主题曲是一个体现世界杯独特氛围和表达足球热情的重要元素。南非世界杯的主题曲是由南非黑人男子合唱团Soweto Gospel Choir演唱的一首名为《Waka Waka (This Time for Africa)》的歌曲。以下是该主题曲的歌词：
（Verse 1）
You're a good soldier
Choosing your battles
Pick yourself up
And dust yourself off
And back in the saddle
You're on the frontline
Everyone's watching
You know it's serious
We're getting closer
This isn't over
（PreChorus）
The pressure's on
You feel it
But you got it all
Believe it
When you fall
Get up, oh oh
And if you fall
Get up, eh eh
Tsamina mina zangalewa
'Cause this is Africa
Tsamina mina, eh eh
Waka waka, eh eh
Tsamina mina zangalewa
This time for Africa
（Chorus）
Listen to your God
This is our motto
Your time to shine
Don't wait in line
Y vamos por todo
People are raising
Their expectations
Go on and feed them
This is your moment
No hesitations
（PreChorus）
The pressure's on
You feel it
But you got it all
Believe it
When you fall
Get up, oh oh
And if you fall
Get up, eh eh
Tsamina mina zangalewa
'Cause this is Africa
Tsamina mina, eh eh
Waka waka, eh eh
Tsamina mina zangalewa
This time for Africa
（Bridge）
Tsamina mina, eh eh
Waka waka, eh eh
Tsamina mina zangalewa
This time for Africa
Tsamina mina, eh eh
Waka waka, eh eh
Tsamina mina zangalewa
Anawa aa
Tsamina mina, eh eh
Waka waka, eh eh
Tsamina mina zangalewa
This time for Africa
（Chorus）
Listen to your God
This is our motto
Your time to shine
Don't wait in line
Y vamos por todo
People are raising
Their expectations
Go on and feed them
This is your moment
No hesitations
（PreChorus）
The pressure's on
You feel it
But you got it all
Believe it
When you fall
Get up, oh oh
And if you fall
Get up, eh eh
Tsamina mina zangalewa
'Cause this is Africa
Tsamina mina, eh eh
Waka waka, eh eh
Tsamina mina zangalewa
Tsamina mina, eh eh
Waka waka, eh eh
Tsamina mina zangalewa
This time for Africa
该歌曲以非洲传统音乐和西班牙语混合，充满了活力和节奏感。通过鼓舞人心的歌词，强调了勇气、团结和自信的重要性，与世界杯这一全球体育盛事相得益彰。这首歌曲在南非世界杯期间深深地吸引了全球球迷，成为了世界范围内的热门主题曲。
